Efficient heuristics to minimize the total tardiness of chemotherapy drug production and delivery

This study considers the production of chemotherapy drugs for cancer treatment. An important factor determining quality service treatment is time patient must wait to receive his or her injection drug. Chemotherapy and delivery are modeled as a scheduling problem combined with vehicle routing problem. The three-stage hybrid flow shop problem, variant multi-trip due dates. objective function minimization total delay To solve this we propose several heuristic algorithms provide solutions within reasonable computation times. Computational experiments used compare performance heuristics applied real data-based random instances.